Partial demolition of and alterations to Littlemore House. Erection of 1no. research and development building (Use Class E) at Littlemore House with ancillary accommodation, clinic, educational floorspace and restaurant and erection of 1 no. research and development building (Use Class E) and 1no. building to accommodate servicing plant and bicycle parking facilities at plot 18 of the Oxford Science Park. Erection of an elevated walkway, linking Littlemore House and plot 18 of the Oxford Science Park, new access arrangements, parking, landscaping, engineering and ground modelling works.